RESUMO
BACKGROUND: Respiratory allergy is characterised by an IgE-mediated reaction. The immune system functions, including IgE production, progressively decline over time, such as growing up and ageing. Molecular-based allergy diagnostic defines sensitisation profile. This study aimed to evaluate the impact of age on serum allergen-specific IgE to molecular component levels in a large sample of subjects. METHODS: Serum IgE to: Phl p1, Bet v1, Ole e1, Cup a1, Par j2, Can f1, Der p2, and Fel d1 were assessed by ISAC method. Sera from 2788 patients, 1230 males (44.1%) and 1558 females (55.9%), median age 23 years (1st and 3rd quartiles: 9.7-49.7 years; age range: 1 month-103 years) were analysed. RESULTS: The number of positive tests (i.e. sensitisation) tended to increase between birth and school-age till young adulthood and then decreased (p < 0.0001) with the exception of Fel d 1 (p = 0.14). A similar age-dependent trend was observed considering the levels of each allergen components: the levels of each allergen component, with the exception of Fel d 1, tended to increase till early adulthood and then to decrease reaching the lowest levels in the elderly. CONCLUSIONS: Allergen-specific IgE production to inhaled molecular components trend to reduce with ageing, but with differences between allergens. This phenomenon should be adequately evaluated managing allergic patients
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Assuntos
Humanos , Masculino , Feminino , Adulto , Imunoglobulina E/análise , Hipersensibilidade Imediata/diagnóstico , Doenças Respiratórias/diagnóstico , Técnicas Imunológicas , Alérgenos/análise , Estudos Retrospectivos , 28599 , Análise de VariânciaRESUMO
BACKGROUND: Respiratory allergy is characterised by an IgE-mediated reaction. The immune system functions, including IgE production, progressively decline over time with growing up and ageing. Molecular-based allergy diagnostic defines sensitisation profile. This study aimed to evaluate the impact of age on serum allergen-specific IgE to molecular component levels in a large sample of subjects. METHODS: Serum IgE to: rCor a11, rPru p3, nJug r3, rAra h8, rGly m4, rCor a8, nPen m1, nAct d8, Bos d 8, and nGal d2 were assessed by ISAC method. Sera from 2795 patients, 1234 males (44.1%) and 1561 females (55.9%), median age 23 years (1st and 3rd quartiles: 9.7-43.7 years; age range: 1 month-103 years) were analysed. RESULTS: The number of positive tests (i.e. sensitisation) tended to increase between birth and school-age until young adulthood and then decreased. A similar age-dependent trend was observed considering the levels of each allergen components: the levels of each allergen component tended to increase until early adulthood, but Gal d 2 and Bos d 8 (rapidly diminishing), and then to decrease over time. However, the pattern is significantly dependent on each single tested food. CONCLUSIONS: Allergen-specific IgE production to food molecular components tend to reduce with ageing, but with differences between allergens. This phenomenon should be adequately evaluated managing allergic patients
No disponible
Assuntos
Humanos , Criança , Adulto , Hipersensibilidade Respiratória/imunologia , Hipersensibilidade Imediata/imunologia , Hipersensibilidade Alimentar/imunologia , 50293 , Alérgenos/imunologia , Estudos RetrospectivosRESUMO
No disponible
Assuntos
Humanos , Anafilaxia/epidemiologia , Hipersensibilidade Alimentar/imunologia , Distribuição por Idade e SexoRESUMO
No disponible
Assuntos
Humanos , Masculino , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/diagnóstico , Asma/metabolismo , Obesidade/diagnóstico , Obesidade/metabolismo , Hipersensibilidade/classificação , Glicemia/análise , Diabetes Mellitus Tipo 2/genética , Diabetes Mellitus Tipo 2/metabolismo , Asma/prevenção & controle , Obesidade/complicações , Hipersensibilidade/metabolismo , Glicemia/metabolismo , Estatísticas não ParamétricasRESUMO
No disponible
